2. Gene
  3. LOXL1 - Loxl1 lysyl oxidase-like 1 Gene

LOXL1 - Loxl1 lysyl oxidase-like 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 315714 | Gene type: protein coding

About LOXL1

Summary

Predicted to enable protein-lysine 6-oxidase activity. Involved in aorta development and response to lipopolysaccharide. Located in acrosomal vesicle and basement membrane. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; exfoliation syndrome; and primary open angle glaucoma. Orthologous to human LOXL1 (Lysyl Oxidase like 1). [provided by Alliance of Genome Resources, Apr 2022]

LOXL1 Products(1)

mRNA Protein Name
NM_001012125.2 NP_001012125.1 lysyl oxidase homolog 1 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in aorta development IEP
IEP: Inferred from expression pattern
18803461 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19218354 RGD
Cellular Component GO Annotation Evidence Reference Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
22382377 RGD
located in basement membrane IDA
IDA: Inferred from direct assay
22382377 RGD
located in extracellular matrix IDA
IDA: Inferred from direct assay
16251195 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysyl oxidase homolog 1

lysyl oxidase homolog 1-like

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-151499A PXS-6302 hydrochloride Inhibitor 99.83% Unkown
HY-151498A PXS-4787 hydrochloride Inhibitor 99.71% Unkown
HY-151498 PXS-4787 Inhibitor / Unkown
HY-151499 PXS-6302 Inhibitor / Unkown
HY-RS07741 LOXL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19707 Loxl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26203 Loxl1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens LOXL1 NCBI NCBI:4016