Panx1 - Pannexin 1 Gene

Rattus norvegicus

Also known as px1

Gene ID: 315435 | Gene type: protein coding

About Panx1

Summary

The protein encoded by this gene is a plasma membrane protein that is a structural component of gap junctions. The encoded protein acts as a homodimer or as a heterodimer with Other isoforms or proteins. Two additional variants have been found, and the isoforms expressed from them are found in the cytoplasm. It is thought that these two isoforms could attenuate the actions of the membrane-bound protein. [provided by RefSeq, Jul 2012]

Panx1 Products(3)

mRNA	Protein	Name
NM_001270548.1	NP_001257477.1	pannexin-1 isoform c
NM_001270549.1	NP_001257478.1	pannexin-1 isoform d
NM_199397.2	NP_955429.1	pannexin-1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables gap junction channel activity	IMP IMP: Inferred from mutant phenotype	14597722	RGD
NOT enables gap junction hemi-channel activity	IDA IDA: Inferred from direct assay	17715132	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	19416975	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19416975	RGD
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	14597722	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	19416975	RGD
enables structural molecule activity	IDA IDA: Inferred from direct assay	17715132	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	19416975	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell signaling	IMP IMP: Inferred from mutant phenotype	14597722	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	17715132	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17715132	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pannexin-1

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103399	Trovafloxacin mesylate	Inhibitor	99.76%	Unkown
HY-A0170	Trovafloxacin	Inhibitor	99.08%	Unkown
HY-B1588	Carbenoxolone	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1137	10Panx	Inhibitor	99.48%	Unkown
HY-B1588S	Carbenoxolone-d4	Inhibitor	/	Unkown
HY-P1138	Scrambled 10Panx	Inhibitor	/	Unkown
HY-RS10021	PANX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16802	Panx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23243	Panx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Panx1	NCBI	NCBI:24145

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