Slc4a8 - solute carrier family 4 member 8 Gene

Rattus norvegicus

Gene ID: 315311 | Gene type: protein coding

About Slc4a8

Summary

Predicted to enable chloride transmembrane transporter activity and sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; inorganic ion transmembrane transport; and regulation of intracellular pH. Predicted to act upstream of or within positive regulation of synaptic vesicle exocytosis and regulation of membrane potential. Located in several cellular components, including axon; glutamatergic synapse; and synaptic vesicle. Biomarker of prediabetes syndrome. Orthologous to human SLC4A8 (solute carrier family 4 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a8 Products(3)

mRNA	Protein	Name
NM_001270794.1	NP_001257723.1	electroneutral sodium bicarbonate exchanger 1 isoform 2
NM_001270795.1	NP_001257724.1	electroneutral sodium bicarbonate exchanger 1 isoform 3
NM_199497.2	NP_955791.1	electroneutral sodium bicarbonate exchanger 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	34584093	RGD
enables sodium,bicarbonate:chloride antiporter activity	IDA IDA: Inferred from direct assay	8189393	RGD
enables sodium,bicarbonate:chloride antiporter activity	IMP IMP: Inferred from mutant phenotype	34584093	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in basolateral protein secretion	IDA IDA: Inferred from direct assay	21195699	RGD
involved in regulation of intracellular pH	IDA IDA: Inferred from direct assay	8189393	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in asymmetric synapse	IDA IDA: Inferred from direct assay	22102085	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	22102085	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	18359573	RGD
located in glial cell projection	IDA IDA: Inferred from direct assay	22102085	RGD
located in glutamatergic synapse	IDA IDA: Inferred from direct assay	22102085	RGD
located in hippocampal mossy fiber	IDA IDA: Inferred from direct assay	22102085	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	22102085	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	17715183	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	34584093	RGD
located in presynapse	IDA IDA: Inferred from direct assay	22102085	RGD
located in symmetric synapse	IDA IDA: Inferred from direct assay	22102085	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	22102085	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	22102085	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	22102085	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

electroneutral sodium bicarbonate exchanger 1

Na-driven Cl-HCO3 exchanger NDCBE1-A	Na-driven Cl-HCO3 exchanger NDCBE1-B
Na-driven Cl-HCO3 exchanger NDCBE1-C	electroneutral Na+-driven Cl-HCO3 exchanger
k-NBC3	solute carrier family 4 (anion exchanger), member 8
solute carrier family 4, sodium bic

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13273	SLC4A8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21937	Slc4a8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28453	Slc4a8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc4a8	NCBI	NCBI:9498

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