Elk1 - ETS transcription factor ELK1 Gene

Rattus norvegicus

Gene ID: 314436 | Gene type: protein coding

About Elk1

Summary

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-Fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Multiple isoforms are produced from this gene by the use of alternative translational start codons. [provided by RefSeq, Mar 2012]

Elk1 Products(1)

mRNA	Protein	Name
NM_001108059.3	NP_001101529.1	ETS domain-containing protein Elk-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11557580	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	18768922	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	11557580	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	17949253	RGD
involved in cellular response to lipid	IDA IDA: Inferred from direct assay	18768922	RGD
involved in cellular response to testosterone stimulus	IEP IEP: Inferred from expression pattern	14766003	RGD
involved in hippocampal neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16549787	RGD
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19029245	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	18322102	RGD
involved in response to fibroblast growth factor	IDA IDA: Inferred from direct assay	17156131	RGD
involved in response to light stimulus	IDA IDA: Inferred from direct assay	10383826	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IDA IDA: Inferred from direct assay	9412502	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16549787	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	16549787	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16549787	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ETS domain-containing protein Elk-1

ELK1, ETS transcription factor

ELK1, member of ETS oncogene family

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152860	Darizmetinib		99.94%	Unkown
HY-135699	TD52		≥95.0%	Unkown
HY-113592	ERK-IN-4	Inhibitor	99.61%	Unkown
HY-RS04305	ELK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-135699A	TD52 dihydrochloride		99.90%	Unkown
HY-111000	BNC-1		/	Unkown
HY-163323	AKR1C3-IN-12	Inhibitor	/	Unkown
HY-RS07131	KCNH8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-122241	MT477	Inhibitor	/	Unkown
HY-RS17329	Elk1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21611	Kcnh8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23784	Elk1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS28129	Kcnh8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Elk1	NCBI	NCBI:2002

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