Errfi1 - ERBB receptor feedback inhibitor 1 Gene

Rattus norvegicus

Also known as Xxx; Ralt; gene 33; RGD1307599

Gene ID: 313729 | Gene type: protein coding

About Errfi1

Summary

Enables SH3 domain binding activity; kinase binding activity; and small GTPase binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and negative regulation of macromolecule metabolic process. Located in cytosol and plasma membrane. Orthologous to human ERRFI1 (ERBB receptor feedback inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Errfi1 Products(1)

mRNA	Protein	Name
NM_001014071.1	NP_001014093.1	ERBB receptor feedback inhibitor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IDA IDA: Inferred from direct assay	11003669	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	17599051	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10749885	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	10749885	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular hyperosmotic response	IEP IEP: Inferred from expression pattern	10749885	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	23384834	RGD
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	15556944	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	15358516	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	15556944	RGD
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19204184	RGD
involved in negative regulation of cardiac muscle hypertrophy in response to stress	IDA IDA: Inferred from direct assay	19204184	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	19204184	RGD
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19204184	RGD
involved in negative regulation of epidermal growth factor-activated receptor activity	IDA IDA: Inferred from direct assay	17599051	RGD
involved in negative regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	19204184	RGD
involved in negative regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	17599051	RGD
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	19204184	RGD
involved in regulation of type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	23384834	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ERBB receptor feedback inhibitor 1

gene 33 polypeptide	mig-6
mitogen-inducible gene 6 protein homolog	receptor-associated late transducer

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04516	ERRFI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19775	Errfi1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26272	Errfi1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Errfi1	NCBI	NCBI:54206

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