EPHB2 - Ephb2 Eph receptor B2 Gene

Rattus norvegicus

Also known as RGD1564232

Gene ID: 313633 | Gene type: protein coding

About EPHB2

Summary

Predicted to enable several functions, including amyloid-beta binding activity; identical protein binding activity; and transmembrane signaling receptor activity. Involved in several processes, including cell junction assembly; positive regulation of nervous system development; and regulation of gene expression. Located in Golgi apparatus; cell surface; and dendritic spine. Is active in glutamatergic synapse. Used to study irritable bowel syndrome and ulcerative colitis. Biomarker of irritable bowel syndrome and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EphB2 (EPH receptor B2). [provided by Alliance of Genome Resources, Apr 2022]

EPHB2 Products(1)

mRNA	Protein	Name
NM_001127319.3	NP_001120791.2	ephrin type-B receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	21113149	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amyloid-beta	IEP IEP: Inferred from expression pattern	23831214	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	33794069	RGD
involved in hindbrain tangential cell migration	IMP IMP: Inferred from mutant phenotype	28276447	RGD
involved in negative regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	33722292	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	21364901	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21113149	RGD
involved in positive regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	19160501	RGD
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	21113149	RGD
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	21364901	RGD
involved in postsynaptic membrane assembly	IDA IDA: Inferred from direct assay	11136979	RGD
involved in postsynaptic membrane assembly	IEP IEP: Inferred from expression pattern	11136979	RGD
involved in postsynaptic membrane assembly	IMP IMP: Inferred from mutant phenotype	11136979	RGD
involved in regulation of T-helper 17 type immune response	IDA IDA: Inferred from direct assay	33722292	RGD
involved in regulation of behavioral fear response	IMP IMP: Inferred from mutant phenotype	26354908	RGD
involved in regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	21364901	RGD
involved in regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	33722292	RGD
involved in tight junction assembly	IDA IDA: Inferred from direct assay	33722292	RGD
involved in vesicle-mediated intercellular transport	IDA IDA: Inferred from direct assay	33722292	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	15965473	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15965473	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	16394100	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11136979	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	11136979	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15965473	RGD
located in postsynapse	IDA IDA: Inferred from direct assay	19160501	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ephrin type-B receptor 2

ephrin type-B receptor 2-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18833	ALW-II-49-7	Inhibitor	99.77%	Unkown
HY-P5438	Srctide	Substrate	99.93%	Unkown
HY-170517	PKMYT1-IN-8	Inhibitor	99.31%	Unkown
HY-157019	UniPR1447	Antagonist	99.46%	Unkown
HY-146375	UniPR505	Antagonist	/	Unkown
HY-P10630	Pep63	Inhibitor	/	Unkown
HY-RS04434	EPHB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17199	Ephb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23651	Ephb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24537	Ephb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990405	Anti-EphB2 Antibody	Inhibitor	99.36%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	EPHB2	NCBI	NCBI:2048
Macaca fascicularis	EPHB2	NCBI	NCBI:102137932
Mus musculus	EPHB2	NCBI	NCBI:13844

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