2. Gene
  3. Ago1 - argonaute RISC component 1 Gene

Ago1 - argonaute RISC component 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Eif2c1

Gene ID: 313594 | Gene type: protein coding

About Ago1

Summary

This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to MicroRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to a C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

Ago1 Products(2)

mRNA Protein Name
NM_001191765.2 NP_001178694.1 protein argonaute-1 isoform 1
NM_001317181.1 NP_001304110.1 protein argonaute-1 isoform 1x
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in regulation of mRNA stability IMP
IMP: Inferred from mutant phenotype
26846850 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein argonaute-1

argonaute 1, RISC catalytic component

argonaute RISC catalytic component 1

eukaryotic translation initiation factor 2C, 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00452 AGO1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18906 Ago1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25397 Ago1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ago1 NCBI NCBI:26523