2. Gene
  3. Eps15 - epidermal growth factor receptor pathway substrate 15 Gene

Eps15 - epidermal growth factor receptor pathway substrate 15 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1307641

Gene ID: 313474 | Gene type: protein coding

About Eps15

Summary

Predicted to enable identical protein binding activity and polyubiquitin modification-dependent protein binding activity. Involved in several processes, including endocytic recycling; positive regulation of receptor recycling; and postsynaptic neurotransmitter receptor internalization. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and early endosome. Is active in glutamatergic synapse. Orthologous to human EPS15 (epidermal growth factor receptor pathway substrate 15). [provided by Alliance of Genome Resources, Apr 2022]

Eps15 Products(1)

mRNA Protein Name
NM_001365390.1 NP_001352319.1 epidermal growth factor receptor substrate 15
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9920862 RGD
Biological Process GO Annotation Evidence Reference Source
involved in endocytic recycling IMP
IMP: Inferred from mutant phenotype
21832070 RGD
involved in positive regulation of receptor recycling IMP
IMP: Inferred from mutant phenotype
21832070 RGD
involved in postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
25023288 RGD
involved in postsynaptic neurotransmitter receptor internalization IEP
IEP: Inferred from expression pattern
25023288 RGD
involved in postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
25023288 RGD
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21832070 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16625367 RGD
located in basal plasma membrane IDA
IDA: Inferred from direct assay
16625367 RGD
located in early endosome IDA
IDA: Inferred from direct assay
21832070 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25023288 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25023288 RGD
is active in postsynaptic endocytic zone IDA
IDA: Inferred from direct assay
35072626 RGD
is active in postsynaptic endocytic zone IMP
IMP: Inferred from mutant phenotype
35072626 RGD
is active in synapse IDA
IDA: Inferred from direct assay
25023288 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

epidermal growth factor receptor substrate 15

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04452 EPS15 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04453 EPS15L1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22489 Eps15 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS29012 Eps15 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eps15 NCBI NCBI:2060