2. Gene
  3. Kdm5a - lysine demethylase 5A Gene

Kdm5a - lysine demethylase 5A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Jarid1a

Gene ID: 312678 | Gene type: protein coding

About Kdm5a

Summary

Predicted to enable several functions, including DNA binding activity; histone H3-tri/di/monomethyl-lysine-4 demethylase activity; and zinc ion binding activity. Involved in histone H3-K4 demethylation; male gonad development; and spermatogenesis. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Biomarker of cryptorchidism. Human ortholog(s) of this gene implicated in ankylosing spondylitis. Orthologous to human KDM5A (lysine demethylase 5A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm5a Products(2)

mRNA Protein Name
NM_001277177.1 NP_001264106.1 lysine-specific demethylase 5A isoform 1
NM_001277178.1 NP_001264107.1 lysine-specific demethylase 5A isoform 2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in male gonad development IEP
IEP: Inferred from expression pattern
24679876 RGD
involved in protein modification process IEP
IEP: Inferred from expression pattern
24679876 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
24679876 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 5A

jumonji, AT rich interactive domain 1A (Rbp2 like)

lysine (K)-specific demethylase 5A

Related Agents

Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100421 CPI-455 Inhibitor 98.95% Unkown
HY-102047B KDOAM-25 citrate Inhibitor 98.56% Unkown
HY-100014 KDM5A-IN-1 Inhibitor 99.64% Unkown
HY-107573 KDM2/7-IN-1 Inhibitor 99.00% Unkown
HY-119397A KDM5-C49 hydrochloride Inhibitor 99.95% Unkown
HY-144501 D18 98.79% Unkown
HY-100764 YUKA1 Inhibitor 99.15% Unkown
HY-100624 Ryuvidine Inhibitor 99.40% Unkown
HY-123419 CPI-4203 Inhibitor ≥99.0% Unkown
HY-102047 KDOAM-25 Inhibitor / Unkown
HY-RS07218 KDM5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100421A CPI-455 hydrochloride Inhibitor / Unkown
HY-102047A KDOAM-25 trihydrochloride Inhibitor / Unkown
HY-119397 KDM5-C49 Inhibitor / Unkown
HY-RS16664 Kdm5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23099 Kdm5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm5a NCBI NCBI:5927