Atg7 - autophagy related 7 Gene

Rattus norvegicus

Also known as Apg7l

Gene ID: 312647 | Gene type: protein coding

About Atg7

Summary

Predicted to enable Atg12 activating enzyme activity; Atg8 activating enzyme activity; and protein homodimerization activity. Involved in several processes, including cellular response to morphine; negative regulation of mitochondrial DNA replication; and negative regulation of oxidative stress-induced neuron death. Located in axon. Used to study high grade glioma. Biomarker of hypertension; myocardial infarction; neurodegenerative disease; and paraplegia. Human ortholog(s) of this gene implicated in autosomal recessive cerebellar ataxia. Orthologous to human Atg7 (Autophagy related 7). [provided by Alliance of Genome Resources, Apr 2022]

Atg7 Products(1)

mRNA	Protein	Name
NM_001012097.1	NP_001012097.1	ubiquitin-like modifier-activating enzyme ATG7

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to morphine	IEP IEP: Inferred from expression pattern	23800874	RGD
involved in cellular response to sodium arsenite	IMP IMP: Inferred from mutant phenotype	25639566	RGD
involved in chaperone-mediated autophagy	IMP IMP: Inferred from mutant phenotype	23434281	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	25241190	RGD
involved in negative regulation of mitochondrial DNA replication	IMP IMP: Inferred from mutant phenotype	23800874	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	23800795	RGD
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	24674959	RGD
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	25639566	RGD
involved in positive regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	25639566	RGD
involved in response to alcohol	IEP IEP: Inferred from expression pattern	24226028	RGD
involved in response to fluoride	IEP IEP: Inferred from expression pattern	24296261	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	21384092	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	17665967	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	25040536	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ubiquitin-like modifier-activating enzyme ATG7

ATG12-activating enzyme E1 ATG7	ATG7 autophagy related 7 homolog
autophagy 7-like	autophagy related 7 homolog
autophagy-related protein 7	ubiquitin-activating enzyme E1-like protein

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0538	Xylitol	Activator	≥98.0%	Yes

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146130	ATG7-IN-2		99.32%	Unkown
HY-145371	ATG7-IN-1	Inhibitor	99.91%	Unkown
HY-146131	ATG7-IN-3		99.26%	Unkown
HY-151914	Antitumor agent-82		/	Unkown
HY-170594	Antitumor agent-192		/	Unkown
HY-W768347	Xylitol-13C5		/	Unkown
HY-173133	Antitumor agent-199	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atg7	NCBI	NCBI:10533

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