Traf2 - Tnf receptor-associated factor 2 Gene

Rattus norvegicus

Gene ID: 311786 | Gene type: protein coding

About Traf2

Summary

Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in negative regulation of glial cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; and tumor necrosis factor-mediated signaling pathway. Located in cell cortex and membrane raft. Part of protein-containing complex. Orthologous to human TRAF2 (TNF Receptor associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Traf2 Products(1)

mRNA	Protein	Name
NM_001107815.2	NP_001101285.1	TNF receptor-associated factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	12050113	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12786973	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	10650002	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12786973	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	9813034	RGD
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	10713108	RGD
involved in tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	10713108	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	12786973	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12786973	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TNF receptor-associated factor 2

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19696B	Tauroursodeoxycholate dihydrate		99.96%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16591	Birinapant		99.70%	Phase 2

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100830	NCB-0846	Inhibitor	99.61%	Unkown
HY-138779	ICCB-19 hydrochloride		99.25%	Unkown
HY-134050	Apostatin-1		99.84%	Unkown
HY-124745	KY-05009		99.88%	Unkown
HY-124762	TNIK-IN-1	Inhibitor	98.86%	Unkown
HY-145293	TNIK-IN-3	Inhibitor	99.79%	Unkown
HY-117469	Triptohypol C		95.44%	Unkown
HY-156502	TINK-IN-1	Inhibitor	98.02%	Unkown
HY-156818	TNIK-IN-7	Inhibitor	99.90%	Unkown
HY-156817	TNIK-IN-6	Inhibitor	96.92%	Unkown
HY-100830A	NCB-0970	Control	/	Unkown
HY-122805	PF-794	Inhibitor	99.19%	Unkown
HY-145292	TNIK-IN-2	Inhibitor	99.68%	Unkown
HY-RS14197	TANK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14968	TRAF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16859	Traf2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23300	Traf2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Traf2	NCBI	NCBI:7186

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