Sox18 - SRY-box transcription factor 18 Gene

About Sox18

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including establishment of endothelial barrier; regulation of transcription by RNA polymerase II; and vasculature development. Predicted to act upstream of or within several processes, including circulatory system development; regulation of transcription, DNA-templated; and stem cell fate specification. Predicted to be located in chromatin and nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in hypotrichosis-lymphedema-telangiectasia syndrome and hypotrichosis-lymphedema-telangiectasia-renal defect syndrome. Orthologous to human SOX18 (SRY-box transcription factor 18). [provided by Alliance of Genome Resources, Apr 2022]