2. Gene
  3. Itch - itchy E3 ubiquitin protein ligase Gene

Itch - itchy E3 ubiquitin protein ligase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 311567 | Gene type: protein coding

About Itch

Summary

Predicted to enable several functions, including Arrestin family protein binding activity; ubiquitin protein Ligase activity; and ubiquitin-like protein Ligase binding activity. Predicted to be involved in several processes, including negative regulation of JNK cascade; negative regulation of NF-kappaB transcription factor activity; and protein ubiquitination. Predicted to act upstream of or within several processes, including cellular protein metabolic process; negative regulation of alpha-beta T cell proliferation; and positive regulation of T cell anergy. Predicted to be located in several cellular components, including cell cortex; cytoplasmic vesicle; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to colocalize with early endosome. Orthologous to human ITCH (itchy E3 ubiquitin protein Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Itch Products(1)

mRNA Protein Name
NM_001005887.2 NP_001005887.2 E3 ubiquitin-protein ligase Itchy homolog
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase Itchy homolog

itch E3 ubiquitin ligase

itchy E3 ubiquitin protein ligase homolog

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0548A Hydroxyzine dihydrochloride Antagonist 99.81% Unkown
HY-B1183 Hydrocortisone acetate Agonist 99.14% Yes
HY-B0548 Hydroxyzine Antagonist 99.72% Unkown
HY-B1173 (+)-Camphor Inhibitor ≥98.0% Unkown
HY-106566 Alclometasone dipropionate ≥96.0% Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99025 Lebrikizumab Inhibitor 99.90% Unkown
HY-P99162 Nemolizumab Inhibitor 99.93% Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-136642 Fluocinolone Agonist 99.66% Phase 4
HY-14939 Vapitadine / Phase 2
Pre-clinical Phase
Bioactive Molecules (29)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-129047 Trypsin Activator 91.00% Unkown
HY-129047A Trypsin (MS grade) Activator 95.00% Unkown
HY-103368 Eact Activator 98.86% Unkown
HY-118069 (R)-ZINC-3573 Agonist 99.83% Unkown
HY-147051 Nelremagpran 99.94% Unkown
HY-148244 MS47134 99.88% Unkown
HY-145997 MRGPRX4 modulator-1 99.09% Unkown
HY-148949 Kallikrein 5-IN-2 98.96% Unkown
HY-103320A Calhex 231 hydrochloride Inhibitor 99.81% Unkown
HY-B1144A Chlormidazole hydrochloride Inhibitor 99.45% Unkown
HY-P1192 GR-73632 Agonist 99.93% Unkown
HY-103320B (1R,2R)-Calhex 231 hydrochloride Control 99.07% Unkown
HY-145153 S-777469 Agonist 98.83% Unkown
HY-108425B (Rac)-AMG8379 Antagonist 99.25% Unkown
HY-108425 AMG8379 Antagonist / Unkown
HY-103320 Calhex 231 Antagonist / Unkown
HY-108425A AMG8380 Antagonist / Unkown
HY-124356 Alcaftadine carboxylic acid / Unkown
HY-135495 AM-0466 Inhibitor / Unkown
HY-143481 Nav1.8-IN-2 Inhibitor / Unkown
HY-157496 EP3 antagonist 7 Antagonist / Unkown
HY-163840 GFRα2/3-IN-1 Inhibitor / Unkown
HY-P5357 SFNGGP-NH2 / Unkown
HY-RS06943 ITCH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124356AS Alcaftadine carboxylic acid-d3 sodium / Unkown
HY-167645 Pramoxine / Unkown
HY-N12040 γ-Isofagarine / Unkown
HY-RS17888 Itch Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24357 Itch Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itch NCBI NCBI:83737
Mus musculus Itch NCBI NCBI:16396