Itga4 - integrin subunit alpha 4 Gene

Rattus norvegicus

Gene ID: 311144 | Gene type: protein coding

About Itga4

Summary

Enables cell adhesion molecule binding activity; fibronectin binding activity; and protein antigen binding activity. Involved in several processes, including clathrin-dependent extracellular exosome endocytosis; neuron projection morphogenesis; and regulation of leukocyte migration. Located in several cellular components, including extracellular exosome; growth cone; and neuronal cell body. Used to study anti-basement membrane glomerulonephritis; diabetic retinopathy; nephritis; and pneumonia. Biomarker of pre-eclampsia. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic Cancer. Orthologous to human ITGA4 (Integrin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Itga4 Products(1)

mRNA	Protein	Name
NM_001107737.1	NP_001101207.1	integrin alpha-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables antigen binding	IPI IPI: Inferred from physical interaction	20124479	RGD
enables cell adhesion molecule binding	IMP IMP: Inferred from mutant phenotype	9773789	RGD
enables fibronectin binding	IMP IMP: Inferred from mutant phenotype	9773789	RGD
enables protein antigen binding	IPI IPI: Inferred from physical interaction	20124479	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20124479	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonogenesis involved in innervation	IMP IMP: Inferred from mutant phenotype	16181811	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	12046991	RGD
involved in clathrin-dependent extracellular exosome endocytosis	IMP IMP: Inferred from mutant phenotype	20124479	RGD
involved in diapedesis	IMP IMP: Inferred from mutant phenotype	8550078	RGD
involved in import into cell	IMP IMP: Inferred from mutant phenotype	20124479	RGD
involved in neuron projection extension	IMP IMP: Inferred from mutant phenotype	16181811	RGD
involved in positive regulation of T cell migration	IMP IMP: Inferred from mutant phenotype	8580084	RGD
involved in positive regulation of leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	7680140	RGD
involved in positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	8550078	RGD
involved in positive regulation of leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	9394821	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	9773789	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12486170	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12486170	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

integrin alpha-4

integrin, alpha 4

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99184	Abrilumab		98.35%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06951	ITGA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17832	Itga4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24300	Itga4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itga4	NCBI	NCBI:3676
Macaca fascicularis	Itga4	NCBI	NCBI:102128433

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