Sema5a - semaphorin 5A Gene

Rattus norvegicus

Gene ID: 310207 | Gene type: protein coding

About Sema5a

Summary

Enables chondroitin sulfate proteoglycan binding activity; heparan sulfate proteoglycan binding activity; and syndecan binding activity. Involved in nervous system development and signal clustering. Located in membrane. Orthologous to human SEMA5A (semaphorin 5A). [provided by Alliance of Genome Resources, Apr 2022]

Sema5a Products(1)

mRNA	Protein	Name
NM_001107659.2	NP_001101129.1	semaphorin-5A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chondroitin sulfate proteoglycan binding	IMP IMP: Inferred from mutant phenotype	15603739	RGD
enables heparan sulfate proteoglycan binding	IMP IMP: Inferred from mutant phenotype	15603739	RGD
enables syndecan binding	IPI IPI: Inferred from physical interaction	15603739	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonal fasciculation	IDA IDA: Inferred from direct assay	15603739	RGD
involved in diencephalon development	IMP IMP: Inferred from mutant phenotype	15603739	RGD
involved in negative regulation of axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	15603739	RGD
involved in positive regulation of axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	15603739	RGD
involved in signal clustering	IMP IMP: Inferred from mutant phenotype	15603739	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	15603739	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

semaphorin-5A

sema F	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
semaphorin-F

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12663	SEMA5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19268	Sema5a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25757	Sema5a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sema5a	NCBI	NCBI:9037
Mus musculus	Sema5a	NCBI	NCBI:20356

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