2. Gene
  3. Twnk - twinkle mtDNA helicase Gene

Twnk - twinkle mtDNA helicase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Peo1

Gene ID: 309441 | Gene type: protein coding

About Twnk

Summary

Predicted to enable several functions, including 5'-3' DNA helicase activity; identical protein binding activity; and protease binding activity. Involved in cellular response to glucose stimulus. Located in mitochondrion. Human ortholog(s) of this gene implicated in Perrault syndrome; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3; chronic progressive external ophthalmoplegia; and mitochondrial DNA depletion syndrome 7. Orthologous to human TWNK (twinkle mtDNA helicase). [provided by Alliance of Genome Resources, Apr 2022]

Twnk Products(1)

mRNA Protein Name
NM_001107599.1 NP_001101069.1 twinkle protein, mitochondrial
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
22743328 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

twinkle protein, mitochondrial

progressive external ophthalmoplegia 1 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15283 TWNK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20832 Twnk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27346 Twnk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Twnk NCBI NCBI:56652