2. Gene
  3. Ercc2 - ERCC excision repair 2, TFIIH core complex helicase subunit Gene

Ercc2 - ERCC excision repair 2, TFIIH core complex helicase subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 308415 | Gene type: protein coding

About Ercc2

Summary

Predicted to enable several functions, including 5'-3' DNA helicase activity; protein C-terminus binding activity; and protein N-terminus binding activity. Involved in embryonic organ development and response to hypoxia. Part of transcription factor TFIIH core complex. Biomarker of asphyxia neonatorum. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic Cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ercc2 Products(2)

mRNA Protein Name
NM_001172809.1 NP_001166280.1 general transcription and DNA repair factor IIH helicase subunit XPD
NM_001172809.1 NP_001166280.1 general transcription and DNA repair factor IIH helicase subunit XPD
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in embryonic organ development IEP
IEP: Inferred from expression pattern
11425516 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
9763211 RGD
Cellular Component GO Annotation Evidence Reference Source
part of transcription factor TFIIH core complex IDA
IDA: Inferred from direct assay
8855220 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

general transcription and DNA repair factor IIH helicase subunit XPD

TFIIH basal transcription factor complex helicase XPD subunit

excision repair cross-complementation group 2

excision repair cross-complementing rodent repair deficiency, complementation group 2

rCG54110-like

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04479 ERCC2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22491 Ercc2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS29014 Ercc2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ercc2 NCBI NCBI:2068