2. Gene
  3. Ercc6 - ERCC excision repair 6, chromatin remodeling factor Gene

Ercc6 - ERCC excision repair 6, chromatin remodeling factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 306274 | Gene type: protein coding

About Ercc6

Summary

Predicted to enable several functions, including ATP binding activity; protein C-terminus binding activity; and protein tyrosine kinase activator activity. Involved in DNA protection; regulation of transcription elongation from RNA polymerase II promoter; and transcription-coupled nucleotide-excision repair. Predicted to be located in nuclear body; nucleolus; and site of DNA damage. Predicted to be part of transcription elongation factor complex. Predicted to be active in nucleus. Used to study Cockayne syndrome B. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Cockayne syndrome (multiple); De Sanctis-Cacchione syndrome; UV-sensitive syndrome; age related macular degeneration 5; and primary ovarian insufficiency 11. Orthologous to human ERCC6 (ERCC excision repair 6, chromatin remodeling factor). [provided by Alliance of Genome Resources, Apr 2022]

Ercc6 Products(1)

mRNA Protein Name
NM_001107296.1 NP_001100766.1 DNA excision repair protein ERCC-6
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in DNA protection IMP
IMP: Inferred from mutant phenotype
31644904 RGD
involved in regulation of transcription elongation by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
31644904 RGD
involved in transcription-coupled nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
31644904 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA excision repair protein ERCC-6

excision repair cross-complementation group 6

excision repair cross-complementing rodent repair deficiency, complementation group 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04483 ERCC6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04484 ERCC6L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04485 ERCC6L2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20400 Ercc6 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21852 Ercc6l Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26909 Ercc6 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS28369 Ercc6l Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ercc6 NCBI NCBI:2074