2. Gene
  3. Vcl - vinculin Gene

Vcl - vinculin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 305679 | Gene type: protein coding

About Vcl

Summary

Enables small GTPase binding activity. Predicted to be involved in several processes, including cell-cell junction assembly; platelet aggregation; and protein localization to cell surface. Predicted to act upstream of or within cell adhesion; plasma membrane bounded cell projection organization; and regulation of cell migration. Located in Z disc; intercalated disc; and sarcolemma. Colocalizes with actin filament; focal adhesion; and stress fiber. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin). [provided by Alliance of Genome Resources, Apr 2022]

Vcl Products(1)

mRNA Protein Name
NM_001107248.1 NP_001100718.1 vinculin
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables small GTPase binding IPI
IPI: Inferred from physical interaction
15506980 RGD
Cellular Component GO Annotation Evidence Reference Source
located in Z disc IDA
IDA: Inferred from direct assay
1514597 RGD
located in actin filament IDA
IDA: Inferred from direct assay
15506980 RGD
located in focal adhesion IDA
IDA: Inferred from direct assay
15506980 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
1514597 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
1514597 RGD
located in stress fiber IDA
IDA: Inferred from direct assay
15506980 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vinculin

metavinculin

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15620 VCL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19870 Vcl Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26369 Vcl Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vcl NCBI NCBI:7414
Mus musculus Vcl NCBI NCBI:22330