Tiam1 - TIAM Rac1 associated GEF 1 Gene

Rattus norvegicus

Gene ID: 304109 | Gene type: protein coding

About Tiam1

Summary

Enables microtubule binding activity and receptor tyrosine kinase binding activity. Involved in several processes, including NMDA selective glutamate receptor signaling pathway; generation of neurons; and regulation of MAPK cascade. Located in several cellular components, including axon; postsynaptic density; and ruffle membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Colocalizes with microtubule. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1). [provided by Alliance of Genome Resources, Apr 2022]

Tiam1 Products(1)

mRNA	Protein	Name
NM_001100558.2	NP_001094028.1	T-lymphoma invasion and metastasis-inducing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	11264310	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12446731	RGD
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	16801538	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of GTPase activity	IMP IMP: Inferred from mutant phenotype	18930714	RGD
involved in cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	22564263	RGD
involved in neuron projection extension	IMP IMP: Inferred from mutant phenotype	20333299	RGD
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	16203995	RGD
involved in positive regulation of Schwann cell chemotaxis	IMP IMP: Inferred from mutant phenotype	16203995	RGD
involved in positive regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	11264310	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	24123220	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	16474385	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	20333299	RGD
involved in protein localization to membrane	IMP IMP: Inferred from mutant phenotype	18930714	RGD
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22564263	RGD
involved in regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	18930714	RGD
involved in regulation of modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	15721239	RGD
involved in regulation of modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	15721239	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	15721239	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	15721239	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	23745104	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	11264310	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	16474385	RGD
is active in extrinsic component of postsynaptic density membrane	IDA IDA: Inferred from direct assay	15721239	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15721239	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	15721239	RGD
located in main axon	IDA IDA: Inferred from direct assay	11264310	RGD
located in microtubule	IDA IDA: Inferred from direct assay	11264310	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11264310	RGD
located in ruffle membrane	IDA IDA: Inferred from direct assay	12446731	RGD
located in somatodendritic compartment	IDA IDA: Inferred from direct assay	23300879	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

T-lymphoma invasion and metastasis-inducing protein 1

T-cell lymphoma invasion and metastasis 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16659	EHT 1864	Inhibitor	99.85%	Unkown
HY-104064	1A-116		99.72%	Unkown
HY-115376	Z62954982	Inhibitor	99.38%	Unkown
HY-P1382A	Rac1 Inhibitor W56 TFA	Inhibitor	99.92%	Unkown
HY-P1382	Rac1 Inhibitor W56	Inhibitor	/	Unkown
HY-RS14515	TIAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18300	Tiam1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24778	Tiam1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tiam1	NCBI	NCBI:7074

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