2. Gene
  3. Smurf2 - SMAD specific E3 ubiquitin protein ligase 2 Gene

Smurf2 - SMAD specific E3 ubiquitin protein ligase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1310067

Gene ID: 303614 | Gene type: protein coding

About Smurf2

Summary

Enables SMAD binding activity and transforming growth factor beta receptor binding activity. Predicted to be involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent protein catabolic process. Predicted to be located in nuclear speck. Predicted to be part of ubiquitin Ligase complex. Predicted to be active in cytoplasm. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein Ligase 2). [provided by Alliance of Genome Resources, Apr 2022]

Smurf2 Products(1)

mRNA Protein Name
NM_001107061.2 NP_001100531.1 E3 ubiquitin-protein ligase SMURF2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables SMAD binding IPI
IPI: Inferred from physical interaction
17347560 RGD
enables transforming growth factor beta receptor binding IPI
IPI: Inferred from physical interaction
17347560 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SMURF2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110204 Heclin Inhibitor 98.21% Unkown
HY-RS13460 SMURF2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20599 Smurf2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27107 Smurf2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smurf2 NCBI NCBI:64750