Top3a - DNA topoisomerase III alpha Gene

Rattus norvegicus

Gene ID: 303194 | Gene type: protein coding

About Top3a

Summary

Predicted to enable DNA Topoisomerase type I (single strand cut, ATP-independent) activity and single-stranded DNA binding activity. Predicted to be involved in DNA topological change; chromosome separation; and mitochondrial DNA metabolic process. Predicted to be located in PML body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Orthologous to human TOP3A (DNA Topoisomerase III alpha). [provided by Alliance of Genome Resources, Apr 2022]

Top3a Products(3)

mRNA	Protein	Name
XM_039087263.1	XP_038943191.1	DNA topoisomerase 3-alpha isoform X1
XM_039087264.1	XP_038943192.1	DNA topoisomerase 3-alpha isoform X2
XM_039087265.1	XP_038943193.1	DNA topoisomerase 3-alpha isoform X3

Protein Preferred Names

Protein Names

DNA topoisomerase 3-alpha

topoisomerase (DNA) III alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14898	TOP3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21791	Top3a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28307	Top3a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Top3a	NCBI	NCBI:7156

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