2. Gene
  3. Lgr5 - leucine rich repeat containing G protein coupled receptor 5 Gene

Lgr5 - leucine rich repeat containing G protein coupled receptor 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Gpr49

Gene ID: 299802 | Gene type: protein coding

About Lgr5

Summary

Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in several processes, including activation of Adenylate Cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; and positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; hair follicle development; and oocyte differentiation. Predicted to be located in nucleoplasm and trans-Golgi network membrane. Predicted to be integral component of plasma membrane. Orthologous to human LGR5 (leucine rich repeat containing G protein-coupled receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Lgr5 Products(2)

mRNA Protein Name
NM_001106784.1 NP_001100254.1 leucine-rich repeat-containing G-protein coupled receptor 5 precursor
NM_001106784.1 NP_001100254.1 leucine-rich repeat-containing G-protein coupled receptor 5 precursor
Protein Preferred Names Protein Names

leucine-rich repeat-containing G-protein coupled receptor 5

G protein-coupled receptor 49

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99406 Petosemtamab Degrader 99.94% Phase 3
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P10810 QPH-FR Inhibitor 98.96% Unkown
HY-148918 E722-2648 Inhibitor / Unkown
HY-RS07619 LGR5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20763 Lgr5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27277 Lgr5 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991454 Anti-LGR5/GPR49 Antibody (18G7H6A3) Inhibitor / Unkown
HY-P99406A Petosemtamab (FUT8-KO) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lgr5 NCBI NCBI:8549