Gfpt1 - glutamine fructose-6-phosphate transaminase 1 Gene

Rattus norvegicus

Also known as GFA; GFAT; Gfpt; GFAT1; GFAT1m

Gene ID: 297417 | Gene type: protein coding

About Gfpt1

Summary

Enables several functions, including amino acid binding activity; glutamine-fructose-6-phosphate transaminase (isomerizing) activity; and identical protein binding activity. Involved in several processes, including fructose 6-phosphate metabolic process; glucosamine biosynthetic process; and negative regulation of glycogen biosynthetic process. Biomarker of familial hyperlipidemia and hyperinsulinism. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12 and obesity. Orthologous to human GFPT1 (glutamine--fructose-6-phosphate transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]

Gfpt1 Products(1)

mRNA	Protein	Name
NM_001005879.1	NP_001005879.1	glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables amino acid binding	IDA IDA: Inferred from direct assay	10898949	RGD
enables carbohydrate binding	IDA IDA: Inferred from direct assay	10898949	RGD
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IDA IDA: Inferred from direct assay	10898949	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	10898949	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in UDP-N-acetylglucosamine metabolic process	IMP IMP: Inferred from mutant phenotype	10898949	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	10604279	RGD
involved in fructose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	10898949	RGD
involved in glucosamine biosynthetic process	IDA IDA: Inferred from direct assay	10898949	RGD
involved in negative regulation of glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	8349040	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	7589852	RGD
involved in response to sucrose	IEP IEP: Inferred from expression pattern	16555472	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

D-fructose-6-phosphate amidotransferase 1	GFAT 1
glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1	glutamine:fructose-6-phosphate amidotransferase 1
hexosephosphate aminotransferase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05384	GFPT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19005	Gfpt1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25494	Gfpt1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gfpt1	NCBI	NCBI:2673

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