Slc22a5 - solute carrier family 22 member 5 Gene

Rattus norvegicus

Also known as CT1; OCTN2; UST2r

Gene ID: 29726 | Gene type: protein coding

About Slc22a5

Summary

Enables (R)-carnitine transmembrane transporter activity. Involved in (R)-carnitine transmembrane transport. Located in basolateral plasma membrane and cytosol. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; and systemic primary carnitine deficiency disease. Orthologous to human SLC22A5 (solute carrier family 22 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a5 Products(1)

mRNA	Protein	Name
NM_019269.1	NP_062142.1	solute carrier family 22 member 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables (R)-carnitine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	28257821	RGD
enables carnitine transmembrane transporter activity	IDA IDA: Inferred from direct assay	9792817	RGD
enables carnitine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	16322553	RGD
enables quaternary ammonium group transmembrane transporter activity	IDA IDA: Inferred from direct assay	10636865	RGD
enables quaternary ammonium group transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	10454528	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in (R)-carnitine transmembrane transport	IDA IDA: Inferred from direct assay	10454528	RGD
involved in (R)-carnitine transmembrane transport	IMP IMP: Inferred from mutant phenotype	28257821	RGD
involved in carnitine transport	IDA IDA: Inferred from direct assay	9792817	RGD
involved in carnitine transport	IMP IMP: Inferred from mutant phenotype	16322553	RGD
involved in quaternary ammonium group transport	IDA IDA: Inferred from direct assay	10636865	RGD
involved in quaternary ammonium group transport	IMP IMP: Inferred from mutant phenotype	10454528	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12080034	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	28257821	RGD
located in cytosol	IDA IDA: Inferred from direct assay	17995936	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	17995936	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

solute carrier family 22 member 5

high-affinity carnitine transporter	high-affinity sodium-dependent carnitine cotransporter
integral membrane transport protein	organic cation/carnitine transporter 2
solute carrier family 22 (organic cation transporter), member 5	solute carrier famil

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13077	SLC22A5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20645	Slc22a5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27155	Slc22a5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc22a5	NCBI	NCBI:6584

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