Gsn - gelsolin Gene

Rattus norvegicus

Gene ID: 296654 | Gene type: protein coding

About Gsn

Summary

Enables actin binding activity. Involved in several processes, including cellular response to cadmium ion; oligodendrocyte development; and phosphatidylinositol-mediated signaling. Located in several cellular components, including myelin sheath; perinuclear region of cytoplasm; and ruffle. Part of protein-containing complex. Biomarker of hypothyroidism and lung disease. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin). [provided by Alliance of Genome Resources, Apr 2022]

Gsn Products(1)

mRNA	Protein	Name
NM_001004080.1	NP_001004080.1	gelsolin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	16280379	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament depolymerization	IMP IMP: Inferred from mutant phenotype	11861757	RGD
involved in actin polymerization or depolymerization	IDA IDA: Inferred from direct assay	16280379	RGD
involved in cellular response to cadmium ion	IDA IDA: Inferred from direct assay	16280379	RGD
involved in oligodendrocyte development	IEP IEP: Inferred from expression pattern	7817780	RGD
involved in positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	24505034	RGD
involved in positive regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	24505034	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	12899944	RGD
involved in response to folic acid	IEP IEP: Inferred from expression pattern	12899944	RGD
involved in tissue regeneration	IEP IEP: Inferred from expression pattern	14574581	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	16280379	RGD
located in apical ectoplasmic specialization	IDA IDA: Inferred from direct assay	11861757	RGD
located in basal ectoplasmic specialization	IDA IDA: Inferred from direct assay	11861757	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	2829631	RGD
located in glial filament	IDA IDA: Inferred from direct assay	25744577	RGD
located in myelin sheath	IDA IDA: Inferred from direct assay	17960831	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16280379	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15823548	RGD
located in ruffle	IDA IDA: Inferred from direct assay	16280379	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gelsolin

ADF	actin-depolymerizing factor
brevin

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133870	Itaconate-alkyne		98.01%	Unkown
HY-176305S	Neurofilament, U-15N		/	Unkown
HY-RS05867	GSN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18449	Gsn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24931	Gsn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gsn	NCBI	NCBI:2934

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