CASK - Cask calcium/calmodulin dependent serine protein kinase Gene

Rattus norvegicus

Gene ID: 29647 | Gene type: protein coding

About CASK

Summary

Enables PDZ domain binding activity; neurexin family protein binding activity; and protein C-terminus binding activity. Involved in several processes, including nervous system development; positive regulation of Insulin secretion; and protein localization to plasma membrane. Located in several cellular components, including apical dendrite; basolateral plasma membrane; and podocyte foot. Part of protein-containing complex. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Orthologous to human CASK (calcium/Calmodulin dependent serine protein kinase). [provided by Alliance of Genome Resources, Apr 2022]

CASK Products(1)

mRNA	Protein	Name
NM_022184.1	NP_071520.1	peripheral plasma membrane protein CASK

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	9660869	RGD
enables neurexin family protein binding	IPI IPI: Inferred from physical interaction	8786425	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9660869	RGD
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	17084383	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15331416	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	10749215	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	18606847	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	24140090	RGD
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	14960569	RGD
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19275891	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical dendrite	IDA IDA: Inferred from direct assay	9660869	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	10710551	RGD
located in ciliary membrane	IDA IDA: Inferred from direct assay	18596612	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12641734	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9660869	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9660869	RGD
located in nucleus	IDA IDA: Inferred from direct assay	18664494	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12641734	RGD
located in podocyte foot	IDA IDA: Inferred from direct assay	15994232	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	9660869	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	24753440	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	9660869	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	18596612	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11356864	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	8786425	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

peripheral plasma membrane protein CASK

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

peripheral plasma membrane protein CASK-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115719	CASK-IN-1	Inhibitor	99.7%	Unkown
HY-RS01938	CASK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18466	Cask Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24947	Cask Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	CASK	NCBI	NCBI:8573

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