Crhbp - corticotropin releasing hormone binding protein Gene

Rattus norvegicus

Also known as Crfbp

Gene ID: 29625 | Gene type: protein coding

About Crhbp

Summary

Enables corticotropin-releasing hormone binding activity. Involved in several processes, including cellular response to estrogen stimulus; cellular response to immobilization stress; and cellular response to organic cyclic compound. Located in several cellular components, including axon; cytoplasmic vesicle; and perikaryon. Biomarker of mental depression; obesity; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in mental depression. Orthologous to human CRHBP (corticotropin releasing hormone binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Crhbp Products(1)

mRNA	Protein	Name
NM_139183.2	NP_631922.1	corticotropin-releasing factor-binding protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables corticotropin-releasing hormone binding	IDA IDA: Inferred from direct assay	1846945	RGD
enables corticotropin-releasing hormone binding	IPI IPI: Inferred from physical interaction	11572971	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	11572971	RGD
enables peptide binding	IPI IPI: Inferred from physical interaction	15223302	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cocaine	IDA IDA: Inferred from direct assay	14751291	RGD
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	15345745	RGD
involved in cellular response to estrogen stimulus	IDA IDA: Inferred from direct assay	15345745	RGD
involved in cellular response to immobilization stress	IDA IDA: Inferred from direct assay	15530648	RGD
involved in hormone metabolic process	IEP IEP: Inferred from expression pattern	15530648	RGD
involved in negative regulation of corticotropin secretion	IDA IDA: Inferred from direct assay	1846945	RGD
involved in synaptic transmission, dopaminergic	IEP IEP: Inferred from expression pattern	18478589	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IDA IDA: Inferred from direct assay	10524337	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10524337	RGD
located in dense core granule	IDA IDA: Inferred from direct assay	10524337	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	1846945	RGD
located in microtubule	IDA IDA: Inferred from direct assay	10524337	RGD
located in multivesicular body	IDA IDA: Inferred from direct assay	10524337	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	10524337	RGD
located in secondary lysosome	IDA IDA: Inferred from direct assay	10524337	RGD
located in varicosity	IDA IDA: Inferred from direct assay	10524337	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

corticotropin-releasing factor-binding protein

CRF-BP	CRF-binding protein
CRH-BP

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176305S	Neurofilament, U-15N		/	Unkown
HY-RS03167	CRHBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19425	Crhbp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25916	Crhbp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crhbp	NCBI	NCBI:1393

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