1. Gene
  2. Usp8 - ubiquitin specific peptidase 8 Gene

Usp8 - ubiquitin specific peptidase 8 Gene

Rattus norvegicus
Gene ID: 296121 | Gene type: protein coding

About Usp8

Summary

Predicted to enable thiol-dependent Deubiquitinase. Involved in cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Located in cytosol and dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with early endosome. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Apr 2022]

Usp8 Products(1)

mRNA Protein Name
NM_001106502.1 NP_001099972.1 ubiquitin carboxyl-terminal hydrolase 8
Gene Ontology
  • Biological Process
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in early endosome IDA
IDA: Inferred from direct assay
25662281 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25505317 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25505317 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
25505317 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 8

ubiquitin specific protease 8

Orthologs Information

Species Symbol Source ID
Homo sapiens Usp8 NCBI NCBI:9101