Eef2 - eukaryotic translation elongation factor 2 Gene

Rattus norvegicus

Also known as Ef-2

Gene ID: 29565 | Gene type: protein coding

About Eef2

Summary

Enables several functions, including 5S rRNA binding activity; actin filament binding activity; and p53 binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; positive regulation of cytoplasmic translation; and response to ischemia. Located in cytosol; membrane raft; and polysomal ribosome. Part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in glaucoma and spinocerebellar ataxia type 26. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Eef2 Products(1)

mRNA	Protein	Name
NM_017245.2	NP_058941.1	elongation factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5S rRNA binding	IDA IDA: Inferred from direct assay	3801485	RGD
enables RNA binding	IDA IDA: Inferred from direct assay	11681712	RGD
enables actin filament binding	IDA IDA: Inferred from direct assay	7988728	RGD
enables p53 binding	IPI IPI: Inferred from physical interaction	12891704	RGD
enables ribosome binding	IDA IDA: Inferred from direct assay	2390990	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to brain-derived neurotrophic factor stimulus	IEP IEP: Inferred from expression pattern	19625250	RGD
involved in glial cell proliferation	IEP IEP: Inferred from expression pattern	7696190	RGD
involved in positive regulation of cytoplasmic translation	IMP IMP: Inferred from mutant phenotype	19625250	RGD
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	2390990	RGD
involved in response to endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	18188169	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	16339744	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	12899944	RGD
involved in response to folic acid	IEP IEP: Inferred from expression pattern	12899944	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	15211596	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	15211596	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16817885	RGD
involved in skeletal muscle cell differentiation	IEP IEP: Inferred from expression pattern	16682826	RGD
involved in skeletal muscle contraction	IEP IEP: Inferred from expression pattern	19188248	RGD
involved in translation at postsynapse	IDA IDA: Inferred from direct assay	20427644	RGD
involved in translation at postsynapse	IEP IEP: Inferred from expression pattern	20427644	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12891704	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20427644	RGD
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	3801485	RGD
located in ribosome	IDA IDA: Inferred from direct assay	12891704	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

elongation factor 2

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-117684	Cabamiquine	Inhibitor	99.93%	Phase 2
HY-117684A	Cabamiquine succinate	Inhibitor	99.80%	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110096	A-484954	Inhibitor	99.34%	Unkown
HY-100576	NH125	Inhibitor	99.63%	Unkown
HY-126396	Sordarin sodium	Inhibitor	≥99.0%	Unkown
HY-146324	PROTAC eEF2K degrader-1	Activator	98.64%	Unkown
HY-120904	AMPK-IN-1	Activator	95.19%	Unkown
HY-112393	TX-1918	Inhibitor	/	Unkown
HY-121828	TX-1123	Inhibitor	/	Unkown
HY-123024	Cefatrizine		/	Unkown
HY-176149	Fluoxetine-Conjugated Platinum(IV) prodrug-1		/	Unkown
HY-RS04180	EEF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04181	EEF2K Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20013	Eef2k Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20725	Eef2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26516	Eef2k Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27237	Eef2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eef2	NCBI	NCBI:1938

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