2. Gene
  3. Myh6 - myosin heavy chain 6 Gene

Myh6 - myosin heavy chain 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Myh7; Myhca; Myosin-7; MyHC-beta; MyHC-slow

Gene ID: 29556 | Gene type: protein coding

About Myh6

Summary

Enables several functions, including ATP binding activity; calcium-dependent ATPase activity; and identical protein binding activity. Involved in several processes, including cellular response to 3,3',5-triiodo-L-thyronine; muscle contraction; and response to heat. Located in mitochondrion and myofibril. Part of muscle Myosin complex. Biomarker of congestive heart failure; hypothyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (Myosin heavy chain 6). [provided by Alliance of Genome Resources, Apr 2022]

Myh6 Products(1)

mRNA Protein Name
NM_017239.2 NP_058935.2 myosin-6
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
10651160 RGD
enables ATP binding IMP
IMP: Inferred from mutant phenotype
15471982 RGD
enables calcium-dependent ATPase activity IMP
IMP: Inferred from mutant phenotype
10651160 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
3693405 RGD
enables microfilament motor activity IMP
IMP: Inferred from mutant phenotype
15020307 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
3693405 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to 3,3',5-triiodo-L-thyronine IEP
IEP: Inferred from expression pattern
17111039 RGD
involved in muscle contraction IMP
IMP: Inferred from mutant phenotype
15020307 RGD
Cellular Component GO Annotation Evidence Reference Source
part of muscle myosin complex IDA
IDA: Inferred from direct assay
3693405 RGD
located in myofibril IDA
IDA: Inferred from direct assay
10651160 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myosin-6

Myosin heavy chain 7

myHC-alpha

myosin heavy chain polypeptide 6 cardiac muscle adult

myosin heavy chain, polypeptide 6, cardiac muscle, alpha

myosin, heavy chain 6, cardiac muscle, alpha

myosin, heavy polypeptide 6, cardiac muscle, alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08904 MYH6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21384 Myh6 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22090 A1cf Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27903 Myh6 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myh6 NCBI NCBI:4624