Homer1 - homer scaffold protein 1 Gene

Rattus norvegicus

Also known as Vesl-1; HOMER1F

Gene ID: 29546 | Gene type: protein coding

About Homer1

Summary

Enables several functions, including identical protein binding activity; scaffold protein binding activity; and type 5 metabotropic glutamate receptor binding activity. A structural constituent of postsynapse. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; protein tetramerization; and regulation of dendritic spine maintenance. Located in dendritic shaft; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with excitatory synapse. Orthologous to human HOMER1 (homer scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Homer1 Products(1)

mRNA	Protein	Name
NM_031707.2	NP_113895.1	homer protein homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled glutamate receptor binding	IPI IPI: Inferred from physical interaction	15758184	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	19345194	RGD
enables molecular adaptor activity	IPI IPI: Inferred from physical interaction	10433269	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9069287	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	9727012	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	10433269	RGD
enables signaling receptor binding	IDA IDA: Inferred from direct assay	9069287	RGD
enables structural constituent of postsynapse	IDA IDA: Inferred from direct assay	17880892	RGD
enables structural constituent of postsynapse	IMP IMP: Inferred from mutant phenotype	17880892	RGD
enables type 5 metabotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	16554037	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	9069287	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	15308308	RGD
involved in protein localization to synapse	IDA IDA: Inferred from direct assay	12867517	RGD
involved in protein tetramerization	IDA IDA: Inferred from direct assay	19345194	RGD
involved in regulation of dendritic spine maintenance	IMP IMP: Inferred from mutant phenotype	19345194	RGD
involved in regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	19345194	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	18932227	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	15813924	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	16554037	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	9069287	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	30021165	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	9069287	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10433269	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17880892	RGD
located in neuron spine	IDA IDA: Inferred from direct assay	19345194	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9069287	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	10433269	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	10433269	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homer protein homolog 1

PSD-Zip45	VASP/Ena-related gene up-regulated during seizure and LTP 1
homer homolog 1	homer scaffolding protein 1
homer, neuronal immediate early gene, 1	scaffold protein

Homer1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Homer1	Q9Z214	Grm5	Mus musculus	Q3UVX5	NMR	23911326

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06283	HOMER1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21139	Homer1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27657	Homer1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Homer1	NCBI	NCBI:9456

Name
Email *

	Sorry, but the email address you supplied was invalid.