Pebp1 - phosphatidylethanolamine binding protein 1 Gene

Rattus norvegicus

Also known as Pbp; HCNP; Rkip

Gene ID: 29542 | Gene type: protein coding

About Pebp1

Summary

Enables ATP binding activity; mitogen-activated protein kinase binding activity; and receptor serine/threonine kinase binding activity. Involved in several processes, including positive regulation of acetylcholine metabolic process; positive regulation of mitotic nuclear division; and regulation of intracellular signal transduction. Located in several cellular components, including mitochondrial outer membrane; rough endoplasmic reticulum; and synaptic vesicle. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in prostate Cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Pebp1 Products(1)

mRNA	Protein	Name
NM_017236.2	NP_058932.1	phosphatidylethanolamine-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10622376	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	14654844	RGD
enables mitogen-activated protein kinase binding	IDA IDA: Inferred from direct assay	10490027	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11585904	RGD
enables receptor serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	27568556	RGD
enables signaling receptor binding	IDA IDA: Inferred from direct assay	10622376	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in MAPK cascade	IDA IDA: Inferred from direct assay	10490027	RGD
involved in eating behavior	IEP IEP: Inferred from expression pattern	16132681	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	18493952	RGD
involved in negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15886202	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15886202	RGD
involved in positive regulation of acetylcholine biosynthetic process	IDA IDA: Inferred from direct assay	10622376	RGD
involved in positive regulation of acetylcholine metabolic process	IDA IDA: Inferred from direct assay	8888012	RGD
involved in positive regulation of cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	14654844	RGD
involved in positive regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	16916643	RGD
involved in regulation of the force of heart contraction	IDA IDA: Inferred from direct assay	16608915	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	17963288	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	7706975	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	10622376	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	18311602	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	11166120	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	18067547	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	18067547	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	11166120	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11166120	RGD
involved in spermatid development	IEP IEP: Inferred from expression pattern	9508097	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	10639732	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	11428049	RGD
located in cell surface	IDA IDA: Inferred from direct assay	11034991	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	7706975	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	11428049	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10622376	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	11428049	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphatidylethanolamine-binding protein 1

23 kDa morphine-binding protein	HCNPpp
P23K	PEBP-1
Raf-1 kinase inhibitor protein	hippocampal cholinergic neurostimulating peptide

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10313	PEBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18075	Pebp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24550	Pebp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pebp1	NCBI	NCBI:5037

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