2. Gene
  3. Pts - 6-pyruvoyl-tetrahydropterin synthase Gene

Pts - 6-pyruvoyl-tetrahydropterin synthase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 29498 | Gene type: protein coding

About Pts

Summary

Enables 6-pyruvoyltetrahydropterin synthase activity. Predicted to act upstream of or within tetrahydrobiopterin biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia A and phenylketonuria. Orthologous to human PTS (6-pyruvoyltetrahydropterin synthase). [provided by Alliance of Genome Resources, Apr 2022]

Pts Products(3)

mRNA Protein Name
NM_001409515.1 NP_001396444.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 2
NM_001409516.1 NP_001396445.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 3
NM_017220.2 NP_058916.1 6-pyruvoyl tetrahydrobiopterin synthase isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables 6-pyruvoyltetrahydropterin synthase activity IDA
IDA: Inferred from direct assay
1939130 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

6-pyruvoyl tetrahydrobiopterin synthase

6-pyruvoyltetrahydropterin synthase

PTP synthase

PTPS

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-106031 F-14512 97.48% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147062 N-Acetyl-D-galactosamine-6-phosphate 99.6% Unkown
HY-W601362 N-Acetyl-D-galactosamine-6-phosphate disodium 98.61% Unkown
HY-143456 Anti-inflammatory agent 18 Inhibitor / Unkown
HY-143457 Anti-inflammatory agent 19 Inhibitor / Unkown
HY-P10230 Sublancin Inhibitor / Unkown
HY-RS11455 PTS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116259 PT-S58 Antagonist / Unkown
HY-RS20244 Pts Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26752 Pts Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pts NCBI NCBI:5805