Ptbp1 - polypyrimidine tract binding protein 1 Gene

Rattus norvegicus

Also known as Ptb; PTB1; Pybp; Pybp1; Pybp2

Gene ID: 29497 | Gene type: protein coding

About Ptbp1

Summary

Enables nucleic acid binding activity and single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including mRNA metabolic process; positive regulation of cellular component organization; and positive regulation of gene expression. Located in cytoplasm; neuron projection terminus; and nucleus. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptbp1 Products(2)

mRNA	Protein	Name
NM_001271057.1	NP_001257986.1	polypyrimidine tract-binding protein 1 isoform a
NM_022516.5	NP_071961.2	polypyrimidine tract-binding protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA binding	IDA IDA: Inferred from direct assay	19273590	RGD
enables regulatory region RNA binding	IDA IDA: Inferred from direct assay	23511971	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1561080	RGD
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	1561080	RGD
enables single-stranded DNA endodeoxyribonuclease activity	IDA IDA: Inferred from direct assay	12269805	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	11696543	RGD
involved in cardiac ventricle development	IEP IEP: Inferred from expression pattern	19590510	RGD
involved in mRNA processing	IMP IMP: Inferred from mutant phenotype	16177139	RGD
involved in nuclear-transcribed mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	15039777	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	15039777	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17400307	RGD
involved in positive regulation of secretory granule organization	IMP IMP: Inferred from mutant phenotype	15039777	RGD
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	19273590	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuron projection terminus	IDA IDA: Inferred from direct assay	17400307	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

polypyrimidine tract-binding protein 1

heterogeneous nuclear ribonucleoprotein I	hnRNP I
pyrimidine binding protein 1	pyrimidine binding protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5960	PTBP1-RNA-binding inhibitor P6 TFA		99.49%	Unkown
HY-167832	PT109	Inhibitor	/	Unkown
HY-RS11351	PTBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17773	Ptbp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24240	Ptbp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptbp1	NCBI	NCBI:5725

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