Slc1a3 - solute carrier family 1 member 3 Gene

Rattus norvegicus

Also known as EAAT1; GLAST; GluT-1; GLAST-1

Gene ID: 29483 | Gene type: protein coding

About Slc1a3

Summary

Enables high-affinity glutamate transmembrane transporter activity. Involved in L-aspartate import across plasma membrane; L-glutamate import across plasma membrane; and malate-aspartate shuttle. Acts upstream of or within L-glutamate transmembrane transport and response to inorganic substance. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and neuronal cell body. Is integral component of plasma membrane. Part of membrane protein complex. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a3 Products(4)

mRNA	Protein	Name
NM_001289941.1	NP_001276870.1	excitatory amino acid transporter 1 isoform 2
NM_001289942.1	NP_001276871.1	excitatory amino acid transporter 1 isoform 3
NM_001289943.1	NP_001276872.1	excitatory amino acid transporter 1 isoform 4
NM_019225.2	NP_062098.1	excitatory amino acid transporter 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	15242733	RGD
enables glutamate:sodium symporter activity	IMP IMP: Inferred from mutant phenotype	1279699	RGD
enables high-affinity L-glutamate transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	1279699	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-aspartate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	1279699	RGD
involved in L-glutamate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	1279699	RGD
acts upstream of or within L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	7723632	RGD
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	15242733	RGD
involved in L-glutamate transmembrane transport	IMP IMP: Inferred from mutant phenotype	10899959	RGD
involved in malate-aspartate shuttle	IDA IDA: Inferred from direct assay	15242733	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	26133720	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	9219972	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11950769	RGD
part of membrane protein complex	IDA IDA: Inferred from direct assay	9334410	RGD
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	15242733	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	26133720	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	26133720	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	1279699	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

excitatory amino acid transporter 1

glial glutamate transporter	glutamate transporter
glutamate/aspartate transporter	sodium-dependent glutamate/aspartate transporter 1
solute carrier family 1 (glial high affinity glutamate transporter), member 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13054	SLC1A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19528	Slc1a3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26023	Slc1a3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc1a3	NCBI	NCBI:6507

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