Por - cytochrome p450 oxidoreductase Gene

Rattus norvegicus

Also known as CYPOR

Gene ID: 29441 | Gene type: protein coding

About Por

Summary

Enables several functions, including iron-cytochrome-c reductase activity; nucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Involved in several processes, including cellular response to hormone stimulus; negative regulation of hydrolase activity; and positive regulation of steroid biosynthetic process. Located in membrane and mitochondrion. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and Cytochrome P450 oxidoreductase deficiency. Orthologous to human POR (Cytochrome P450 oxidoreductase). [provided by Alliance of Genome Resources, Apr 2022]

Por Products(1)

mRNA	Protein	Name
NM_031576.2	NP_113764.1	NADPH--cytochrome P450 reductase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables FMN binding	IMP IMP: Inferred from mutant phenotype	16928691	RGD
enables NADP binding	IDA IDA: Inferred from direct assay	9774150	RGD
enables NADP binding	IMP IMP: Inferred from mutant phenotype	16928691	RGD
enables NADPH-hemoprotein reductase activity	IDA IDA: Inferred from direct assay	9774150	RGD
enables NADPH-hemoprotein reductase activity	IMP IMP: Inferred from mutant phenotype	16928691	RGD
enables cytochrome-b5 reductase activity, acting on NAD(P)H	IDA IDA: Inferred from direct assay	16055078	RGD
enables electron transfer activity	IDA IDA: Inferred from direct assay	19171935	RGD
enables enzyme binding	IDA IDA: Inferred from direct assay	9774150	RGD
enables enzyme binding	IMP IMP: Inferred from mutant phenotype	16928691	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	11350928	RGD
enables flavin adenine dinucleotide binding	IMP IMP: Inferred from mutant phenotype	16928691	RGD
enables hydrolase activity	IDA IDA: Inferred from direct assay	16226717	RGD
enables iron-cytochrome-c reductase activity	IDA IDA: Inferred from direct assay	15823091	RGD
enables nitric oxide dioxygenase NAD(P)H activity	IDA IDA: Inferred from direct assay	19152507	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in carnitine metabolic process	IEP IEP: Inferred from expression pattern	16616465	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IEP IEP: Inferred from expression pattern	19077323	RGD
involved in cellular response to gonadotropin stimulus	IEP IEP: Inferred from expression pattern	19077323	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	19077323	RGD
involved in demethylation	IDA IDA: Inferred from direct assay	19171935	RGD
involved in fatty acid oxidation	IDA IDA: Inferred from direct assay	17400174	RGD
involved in flavonoid metabolic process	IEP IEP: Inferred from expression pattern	18803703	RGD
involved in internal peptidyl-lysine acetylation	IDA IDA: Inferred from direct assay	18194664	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19264869	RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	19264869	RGD
involved in negative regulation of lipase activity	IDA IDA: Inferred from direct assay	18801337	RGD
involved in nitrate catabolic process	IDA IDA: Inferred from direct assay	16527817	RGD
involved in nitric oxide catabolic process	IDA IDA: Inferred from direct assay	19152507	RGD
involved in nitric oxide catabolic process	IMP IMP: Inferred from mutant phenotype	19152507	RGD
involved in positive regulation of cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	19264869	RGD
involved in positive regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	19264869	RGD
involved in positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19264869	RGD
involved in positive regulation of steroid hormone biosynthetic process	IDA IDA: Inferred from direct assay	2495435	RGD
involved in regulation of cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	19264869	RGD
involved in regulation of growth plate cartilage chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	19264869	RGD
involved in response to dexamethasone	IDA IDA: Inferred from direct assay	27856527	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	17392395	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19265259	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NADPH--cytochrome P450 reductase

CPR	P450 (cytochrome) oxidoreductase
P450R	cytochrome P450 reductase

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0083	Ornipressin	Agonist	99.63%	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10880	POR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P0083A	Ornipressin acetate	Agonist	/	Unkown
HY-RS17068	Por Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23512	Por Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Por	NCBI	NCBI:5447
Macaca fascicularis	Por	NCBI
Mus musculus	Por	NCBI	NCBI:18984
Macaca mulatta	Por	NCBI	NCBI:715888

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