Col1a1 - collagen type I alpha 1 chain Gene

Rattus norvegicus

Also known as COLIA1

Gene ID: 29393 | Gene type: protein coding

About Col1a1

Summary

Predicted to enable identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent. Involved in several processes, including cellular response to growth factor stimulus; cellular response to mechanical stimulus; and cellular response to retinoic acid. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and secretory granule. Used to study cholestasis and non-alcoholic fatty liver disease. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; liver disease (multiple); pulmonary fibrosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (Collagen type I alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col1a1 Products(1)

mRNA	Protein	Name
NM_053304.1	NP_445756.1	collagen alpha-1(I) chain precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15817460	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	2016852	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	16972247	RGD
involved in cellular response to fluoride	IEP IEP: Inferred from expression pattern	21093551	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	32065356	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	22615126	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	1921334	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	19362560	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	17485223	RGD
involved in cellular response to vitamin E	IEP IEP: Inferred from expression pattern	23722449	RGD
acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway	IDA IDA: Inferred from direct assay	10970885	RGD
involved in ossification	IEP IEP: Inferred from expression pattern	14595530	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	10679825	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	2456904	RGD
involved in response to fluoride	IEP IEP: Inferred from expression pattern	15552839	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	10051504	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	11918316	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	20818503	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	11748224	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	15042712	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	20397200	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20818503	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	10679825	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	21842416	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	23069578	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	2659889	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	15609627	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

collagen alpha-1(I) chain

alpha-1 type I collagen	collagen, type 1, alpha 1
collagen, type I, alpha 1	procollagen type I, alpha 1
procollagen, type 1, alpha 1	type I-alpha 1 collagen

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151932	FXR agonist 3	Agonist	95.94%	Unkown
HY-47888	PLN-1474	Inhibitor	99.35%	Unkown
HY-120006A	(rel)-AR234960	Agonist	98.95%	Unkown
HY-146434	TGFβ-IN-2	Inhibitor	99.37%	Unkown
HY-147195	QH536	Inhibitor	/	Unkown
HY-154979	Anti-hepatic fibrosis agent 2		/	Unkown
HY-155328	GK444	Inhibitor	/	Unkown
HY-172258	5-HT2B antagonist-2	Inhibitor	/	Unkown
HY-175496	Acid Ceramidase-IN-3	Inhibitor	/	Unkown
HY-176737	TGF-β1/Smad-IN-1	Inhibitor	/	Unkown
HY-RS02970	COL1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16961	Col1a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23404	Col1a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Col1a1	NCBI	NCBI:1277

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