2. Gene
  3. Lrp5 - LDL receptor related protein 5 Gene

Lrp5 - LDL receptor related protein 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 293649 | Gene type: protein coding

About Lrp5

Summary

Predicted to enable Wnt-activated receptor activity; Wnt-protein binding activity; and coreceptor activity involved in Wnt signaling pathway. Involved in response to peptide hormone; response to radiation; and retina vasculature morphogenesis in camera-type eye. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Used to study autosomal dominant polycystic kidney disease and polycystic liver disease. Biomarker of osteonecrosis; osteoporosis; and tendinitis. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to human LRP5 (LDL receptor related protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Lrp5 Products(1)

mRNA Protein Name
NM_001106321.2 NP_001099791.2 low-density lipoprotein receptor-related protein 5 precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
15962290 RGD
involved in retina vasculature morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
32833527 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 5

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125146 BMD4503-2 99.21% Unkown
HY-RS16292 Lrp5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-E70390 C1s Enzyme Antagonist / Unkown
HY-RS07800 LRP5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-169508 BMD4503-1 Modulator / Unkown
HY-RS24282 Lrp5 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp5 NCBI NCBI:4041