2. Gene
  3. Smad2 - SMAD family member 2 Gene

Smad2 - SMAD family member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Madh2

Gene ID: 29357 | Gene type: protein coding

About Smad2

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; SMAD binding activity; and enzyme binding activity. Predicted to contribute to DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including adrenal gland development; regulation of gene expression; and transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study hepatocellular carcinoma. Biomarker of colon Cancer and myocardial infarction. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian Cancer. Orthologous to human SMAD2 (Smad Family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Smad2 Products(4)

mRNA Protein Name
NM_001277450.1 NP_001264379.1 mothers against decapentaplegic homolog 2
NM_019191.2 NP_062064.1 mothers against decapentaplegic homolog 2
NM_001277450.1 NP_001264379.1 mothers against decapentaplegic homolog 2
NM_019191.2 NP_062064.1 mothers against decapentaplegic homolog 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16362038 RGD
Biological Process GO Annotation Evidence Reference Source
involved in SMAD protein signal transduction IMP
IMP: Inferred from mutant phenotype
22073128 RGD
involved in adrenal gland development IDA
IDA: Inferred from direct assay
12844345 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
32065356 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
33409963 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15987742 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22073128 RGD
involved in signal transduction involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22073128 RGD
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22073128 RGD
Cellular Component GO Annotation Evidence Reference Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
16959941 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 2

SMAD 2

mad-related protein 2

mothers against DPP homolog 2

Related Agents

Approval
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99720 Luspatercept Inhibitor 98.92% Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N2037A Higenamine hydrochloride 99.52% Phase 1
HY-N2037 Higenamine 98.91% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99351 Andecaliximab Inhibitor 95.00% Phase 3
Pre-clinical Phase
Bioactive Molecules (34)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-116084 Trimethylamine N-oxide Activator ≥98.0% Unkown
HY-100830 NCB-0846 Inhibitor 99.61% Unkown
HY-108915 Trimethylamine N-oxide dihydrate Activator ≥98.0% Unkown
HY-116084S Trimethylamine N-oxide-d9 Activator 99.76% Unkown
HY-N6985 Baccatin III 99.19% Unkown
HY-100444 SIS3 free base Inhibitor 98.11% Unkown
HY-144043 ALK5-IN-8 Inhibitor 98.06% Unkown
HY-18766 EW-7195 Inhibitor 98.84% Unkown
HY-100448A Butaprost 99.2% Unkown
HY-123900 AZ12799734 Inhibitor 98.07% Unkown
HY-122856 AZ12601011 Inhibitor 99.88% Unkown
HY-118528A TP0427736 hydrochloride Inhibitor 99.22% Unkown
HY-P10414A Klotho-derived peptide 1 hydrochloride Inhibitor 98.57% Unkown
HY-N4107 Phyllanthin Inhibitor 99.96% Unkown
HY-100830A NCB-0970 Control / Unkown
HY-116084S1 Trimethylamine-N-oxide-13C3 Activator / Unkown
HY-117511 HJC0123 / Unkown
HY-120973 Butaprost free acid / Unkown
HY-149136 MORF-627 Inhibitor / Unkown
HY-161398 TGFβRII-IN-3 / Unkown
HY-162404 Smad2/3-IN-2 Inhibitor / Unkown
HY-162405 Smad2/3-IN-1 Inhibitor / Unkown
HY-168607 ALK5-IN-83 Inhibitor / Unkown
HY-170578 SIRT2-IN-17 Inhibitor / Unkown
HY-172108 TGFβRI-IN-7 Inhibitor / Unkown
HY-P10359 TAT-QFNP12 Inhibitor / Unkown
HY-P10363 Tiger17 Activator / Unkown
HY-P10414 Klotho-derived peptide 1 Inhibitor / Unkown
HY-RS13393 SMAD2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W108953 Myristoyl tetrapeptide-12 Activator / Unkown
HY-118528 TP0427736 Inhibitor / Unkown
HY-N2037AS1 Higenamine-d4-1 hydrochloride / Unkown
HY-RS17208 Smad2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23660 Smad2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991316 KD014 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad2 NCBI NCBI:4087
Mus musculus Smad2 NCBI NCBI:17126