Itgb3 - integrin subunit beta 3 Gene

Rattus norvegicus

Also known as GPIIIa

Gene ID: 29302 | Gene type: protein coding

About Itgb3

Summary

Contributes to fibrinogen binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of signal transduction. Located in apical plasma membrane and cell surface. Part of Integrin complex. Colocalizes with focal adhesion. Biomarker of Bacterial pneumonia; glomerulonephritis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (Integrin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]

Itgb3 Products(1)

mRNA	Protein	Name
NM_153720.2	NP_714942.1	integrin beta-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to fibrinogen binding	IDA IDA: Inferred from direct assay	11278919	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	1585837	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin-like growth factor stimulus	IEP IEP: Inferred from expression pattern	21932665	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	12856576	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	12242040	RGD
involved in embryo implantation	IEP IEP: Inferred from expression pattern	16528553	RGD
involved in maintenance of postsynaptic specialization structure	EXP EXP: Inferred from Experiment	20935643	RGD
involved in maintenance of postsynaptic specialization structure	IDA IDA: Inferred from direct assay	20935643	RGD
involved in negative regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	9585425	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	17620283	RGD
involved in positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17157995	RGD
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	19331142	RGD
involved in positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	8603604	RGD
involved in positive regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	17868879	RGD
involved in positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	10869268	RGD
involved in positive regulation of glomerular mesangial cell proliferation	IMP IMP: Inferred from mutant phenotype	20135641	RGD
involved in positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	11705748	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	12606526	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	19723557	RGD
involved in regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17157995	RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping	EXP EXP: Inferred from Experiment	20935643	RGD
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IDA IDA: Inferred from direct assay	20935643	RGD
involved in regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	7689577	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	12654355	RGD
involved in response to platelet-derived growth factor	IEP IEP: Inferred from expression pattern	21932665	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	21426865	RGD
located in cell surface	IDA IDA: Inferred from direct assay	11278919	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	21426865	RGD
is active in glycinergic synapse	EXP EXP: Inferred from Experiment	20935643	RGD
is active in glycinergic synapse	IDA IDA: Inferred from direct assay	20935643	RGD
part of integrin complex	IDA IDA: Inferred from direct assay	17157995	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

integrin beta-3

integrin beta 3 (Cd61)	integrin, beta 3
platelet membrane glycoprotein IIIa

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06966	ITGB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06967	ITGB3BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18524	Itgb3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25006	Itgb3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itgb3	NCBI	NCBI:3690
Macaca fascicularis	Itgb3	NCBI	NCBI:102117791
Mus musculus	Itgb3	NCBI	NCBI:16416

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