Penk - proenkephalin Gene

Rattus norvegicus

Also known as Enk; Penk1; Penk2; Penk-rs

Gene ID: 29237 | Gene type: protein coding

About Penk

Summary

Predicted to enable Opioid Receptor binding activity. Involved in several processes, including cellular response to organic cyclic compound; general adaptation syndrome, behavioral process; and locomotory exploration behavior. Located in several cellular components, including cell body fiber; perikaryon; and symmetric synapse. Is active in neuronal dense core vesicle lumen and synaptic vesicle lumen. Used to study heroin dependence. Biomarker of Parkinson's disease; alcohol use disorder; dystonia; and spinal disease. Orthologous to human PENK (proenkephalin). [provided by Alliance of Genome Resources, Apr 2022]

Penk Products(1)

mRNA	Protein	Name
NM_017139.2	NP_058835.2	proenkephalin-A precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	9826786	RGD
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	11595755	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	8584038	RGD
involved in cellular response to virus	IEP IEP: Inferred from expression pattern	8411369	RGD
involved in cellular response to vitamin D	IEP IEP: Inferred from expression pattern	8584038	RGD
involved in general adaptation syndrome, behavioral process	IEP IEP: Inferred from expression pattern	23665402	RGD
involved in glial cell proliferation	IEP IEP: Inferred from expression pattern	9221949	RGD
involved in locomotory exploration behavior	IMP IMP: Inferred from mutant phenotype	23368426	RGD
involved in osteoblast differentiation	IEP IEP: Inferred from expression pattern	8584038	RGD
involved in positive regulation of behavioral fear response	IMP IMP: Inferred from mutant phenotype	23368426	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	10426412	RGD
involved in response to epinephrine	IEP IEP: Inferred from expression pattern	8784263	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	12503826	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	9581644	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	20184566	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	22200548	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	15300902	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	8784263	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	25086310	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	23410195	RGD
involved in synaptic signaling via neuropeptide	EXP EXP: Inferred from Experiment	355888	RGD
involved in synaptic signaling via neuropeptide	IMP IMP: Inferred from mutant phenotype	355888	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	23912034	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	20686827	RGD
located in cell body fiber	IDA IDA: Inferred from direct assay	20686827	RGD
located in dendrite	IDA IDA: Inferred from direct assay	20686827	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	2695900	RGD
is active in neuronal dense core vesicle lumen	IDA IDA: Inferred from direct assay	8847409	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	23912034	RGD
located in symmetric synapse	IDA IDA: Inferred from direct assay	20686827	RGD
is active in synaptic vesicle lumen	IDA IDA: Inferred from direct assay	8847409	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proenkephalin-A

enkephalin	preproenkephalin 2
proenkephalin 1	proenkephalin 2
proenkephalin related sequence

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10326	PENK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19363	Penk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25855	Penk Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Penk	NCBI	NCBI:5179

Name
Email *

	Sorry, but the email address you supplied was invalid.