CLCN2 - Clcn2 chloride voltage-gated channel 2 Gene

Rattus norvegicus

Also known as ClC-2

Gene ID: 29232 | Gene type: protein coding

About CLCN2

Summary

Enables voltage-gated Chloride Channel activity. Involved in chloride transport and lung development. Located in dendrite and perikaryon. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Apr 2022]

CLCN2 Products(1)

mRNA	Protein	Name
NM_017137.2	NP_058833.1	chloride channel protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables voltage-gated chloride channel activity	IDA IDA: Inferred from direct assay	1311421	RGD
enables voltage-gated chloride channel activity	IMP IMP: Inferred from mutant phenotype	1334533	RGD
enables voltage-gated monoatomic anion channel activity	IDA IDA: Inferred from direct assay	22405205	RGD
enables volume-sensitive chloride channel activity	IMP IMP: Inferred from mutant phenotype	1334533	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular hypotonic response	IMP IMP: Inferred from mutant phenotype	1334533	RGD
involved in chloride transport	IDA IDA: Inferred from direct assay	1311421	RGD
involved in lung development	IMP IMP: Inferred from mutant phenotype	14711803	RGD
involved in positive regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	29344669	RGD
involved in positive regulation of voltage-gated chloride channel activity	IMP IMP: Inferred from mutant phenotype	29344669	RGD
involved in regulation of membrane depolarization during action potential	IMP IMP: Inferred from mutant phenotype	8816717	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in astrocyte end-foot	IDA IDA: Inferred from direct assay	11068136	RGD
located in axon initial segment	IDA IDA: Inferred from direct assay	11068136	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12967985	RGD
located in dendritic spine membrane	IDA IDA: Inferred from direct assay	11068136	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	12967985	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

chloride channel protein 2

chloride channel 2

chloride channel, voltage-sensitive 2

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0680	Lubiprostone (hemiketal)	Activator	/	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02754	CLCN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22442	Clcn2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28965	Clcn2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	CLCN2	NCBI	NCBI:1181

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