Lrp2 - LDL receptor related protein 2 Gene

Rattus norvegicus

Gene ID: 29216 | Gene type: protein coding

About Lrp2

Summary

Enables several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including endocytic Hemoglobin import into cell; positive regulation of transport; and response to vitamin D. Located in several cellular components, including apical plasma membrane; axonal growth cone; and brush border membrane. Part of receptor complex. Used to study hypertension. Biomarker of autosomal dominant polycystic kidney disease; end stage renal disease; membranous glomerulonephritis; and nephrosis. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrp2 Products(1)

mRNA	Protein	Name
NM_030827.2	NP_110454.2	low-density lipoprotein receptor-related protein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	21325834	RGD
enables hemoglobin binding	IDA IDA: Inferred from direct assay	11805171	RGD
enables hormone binding	IPI IPI: Inferred from physical interaction	15131016	RGD
enables insulin-like growth factor I binding	IDA IDA: Inferred from direct assay	16306401	RGD
enables low-density lipoprotein particle receptor binding	IPI IPI: Inferred from physical interaction	22349218	RGD
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	16143106	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10769163	RGD
enables protein transporter activity	IDA IDA: Inferred from direct assay	16306401	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	21372499	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid-beta clearance	IMP IMP: Inferred from mutant phenotype	16306401	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	15266031	RGD
involved in cellular response to growth factor stimulus	IMP IMP: Inferred from mutant phenotype	16306401	RGD
involved in chemoattraction of axon	IMP IMP: Inferred from mutant phenotype	26598525	RGD
involved in endocytic hemoglobin import into cell	IMP IMP: Inferred from mutant phenotype	11805171	RGD
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	15670845	RGD
involved in endosomal transport	IMP IMP: Inferred from mutant phenotype	9039057	RGD
involved in metal ion transport	IDA IDA: Inferred from direct assay	15126248	RGD
involved in metanephric proximal tubule development	IEP IEP: Inferred from expression pattern	30645697	RGD
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	10766831	RGD
involved in positive regulation of lipoprotein transport	IMP IMP: Inferred from mutant phenotype	10766831	RGD
involved in protein import	IMP IMP: Inferred from mutant phenotype	16128811	RGD
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	11595644	RGD
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	8626514	RGD
involved in response to X-ray	IDA IDA: Inferred from direct assay	12121845	RGD
involved in response to leptin	IMP IMP: Inferred from mutant phenotype	17324488	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	9541123	RGD
involved in response to vitamin D	IEP IEP: Inferred from expression pattern	9541123	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15266031	RGD
involved in transcytosis	IMP IMP: Inferred from mutant phenotype	14657389	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10919857	RGD
located in axonal growth cone	IDA IDA: Inferred from direct assay	26598525	RGD
located in brush border	IDA IDA: Inferred from direct assay	11912251	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	6752952	RGD
located in cell surface	IDA IDA: Inferred from direct assay	10766831	RGD
located in endosome	IDA IDA: Inferred from direct assay	17063000	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	17063000	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	17324488	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	22349218	RGD
part of receptor complex	IDA IDA: Inferred from direct assay	19202329	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

low-density lipoprotein receptor-related protein 2

LRP-2	glycoprotein 330
gp330	low density lipoprotein-related protein 2
megalin

Lrp2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Lrp2	P98158	Dab2	Rattus norvegicus	O88797	Anti Bait CoIP	10769163

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07797	LRP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17962	Lrp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24433	Lrp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrp2	NCBI	NCBI:4036

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