Arg2 - arginase 2 Gene

Rattus norvegicus

Gene ID: 29215 | Gene type: protein coding

About Arg2

Summary

Enables Arginase activity and nitric-oxide synthase binding activity. Involved in several processes, including arginine catabolic process to ornithine; cellular response to cytokine stimulus; and cellular response to lipid. Located in mitochondrion. Used to study hypertension. Biomarker of acute kidney failure; end stage renal disease; hypertension; and ureteral obstruction. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (Arginase 2). [provided by Alliance of Genome Resources, Apr 2022]

Arg2 Products(1)

mRNA	Protein	Name
NM_019168.2	NP_062041.2	arginase-2, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables arginase activity	IDA IDA: Inferred from direct assay	11829529	RGD
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	16537391	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16537391	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in arginine catabolic process to ornithine	IDA IDA: Inferred from direct assay	15753084	RGD
involved in arginine metabolic process	IMP IMP: Inferred from mutant phenotype	16537391	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	11250887	RGD
involved in cellular response to interleukin-4	IEP IEP: Inferred from expression pattern	14618299	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	11250887	RGD
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	11250887	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	18192591	RGD
involved in maternal process involved in female pregnancy	IEP IEP: Inferred from expression pattern	16735458	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	10050048	RGD
involved in negative regulation of nitric-oxide synthase activity	IMP IMP: Inferred from mutant phenotype	16537391	RGD
involved in negative regulation of striated muscle contraction	IMP IMP: Inferred from mutant phenotype	16537391	RGD
involved in regulation of L-arginine import across plasma membrane	IDA IDA: Inferred from direct assay	11120661	RGD
involved in regulation of nitric oxide biosynthetic process	IEP IEP: Inferred from expression pattern	11829529	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	16168957	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	15458774	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	15735325	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	16570515	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	15254879	RGD
involved in response to herbicide	IEP IEP: Inferred from expression pattern	20388547	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	14532164	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	20039818	RGD
involved in response to mercury ion	IEP IEP: Inferred from expression pattern	17874066	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	18348861	RGD
involved in response to selenium ion	IEP IEP: Inferred from expression pattern	14624471	RGD
involved in response to vitamin E	IEP IEP: Inferred from expression pattern	14624471	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15888029	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	16537391	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

arginase-2, mitochondrial

AII type II arginase	arginase II
arginase type II	kidney-type arginase
non-hepatic arginase	type II arginase

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112885B	nor-NOHA monoacetate	Inhibitor	99.96%	Unkown
HY-112885C	nor-NOHA dihydrochloride		98.85%	Unkown
HY-112885A	nor-NOHA acetate		≥99.0%	Unkown
HY-RS00908	ARG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P4750	Acetyl-(D-Arg2)-GRF (1-29) amide (human)	Antagonist	99.67%	Unkown
HY-112885	nor-NOHA		/	Unkown
HY-P10555	(D-Arg2, Sar 4)-Dermorphin (1-4)	Agonist	/	Unkown
HY-RS17404	Arg2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23859	Arg2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arg2	NCBI	NCBI:384
Mus musculus	Arg2	NCBI	NCBI:11847

Name
Email *

	Sorry, but the email address you supplied was invalid.