2. Gene
  3. Irf8 - interferon regulatory factor 8 Gene

Irf8 - interferon regulatory factor 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ICSBP; Icsbp1

Gene ID: 292060 | Gene type: protein coding

About Irf8

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cellular response to interferon-gamma; mononuclear cell differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including defense response to protozoan; regulation of gene expression; and response to bacterium. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 32A and immunodeficiency 32B. Orthologous to human IRF8 (interferon regulatory factor 8). [provided by Alliance of Genome Resources, Apr 2022]

Irf8 Products(1)

mRNA Protein Name
NM_001008722.2 NP_001008722.1 interferon regulatory factor 8
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15688197 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
21261980 RGD
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
21261980 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon regulatory factor 8

interferon consensus sequence binding protein 1

transcription factor ICSBP

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06912 IRF8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18767 Irf8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25255 Irf8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irf8 NCBI NCBI:3394