2. Gene
  3. Aars1 - alanyl-tRNA synthetase 1 Gene

Aars1 - alanyl-tRNA synthetase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Aars

Gene ID: 292023 | Gene type: protein coding

About Aars1

Summary

Enables several functions, including ATP binding activity; alanine-tRNA Ligase activity; and tRNA binding activity. Involved in alanyl-tRNA aminoacylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N and developmental and epileptic encephalopathy 29. Orthologous to human AARS1 (alanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Aars1 Products(1)

mRNA Protein Name
NM_001100517.1 NP_001093987.1 alanine--tRNA ligase, cytoplasmic
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IPI
IPI: Inferred from physical interaction
2040280 RGD
enables alanine-tRNA ligase activity IDA
IDA: Inferred from direct assay
2040280 RGD
enables amino acid binding IPI
IPI: Inferred from physical interaction
2040280 RGD
enables tRNA binding IPI
IPI: Inferred from physical interaction
2040280 RGD
Biological Process GO Annotation Evidence Reference Source
involved in alanyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
2040280 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alanine--tRNA ligase, cytoplasmic

alaRS

alanyl-tRNA synthetase, cytoplasmic

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00028 AARS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-147908 Adenosine receptor inhibitor 2 Inhibitor / Unkown
HY-151139 LJ-4517 Antagonist / Unkown
HY-RS17458 Aars1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23915 Aars1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aars1 NCBI NCBI:16
Mus musculus Aars1 NCBI