Psen1 - presenilin 1 Gene

Rattus norvegicus

Gene ID: 29192 | Gene type: protein coding

About Psen1

Summary

Enables endopeptidase activity. Involved in several processes, including negative regulation of neuron apoptotic process; neural retina development; and proteolysis. Located in several cellular components, including cytoplasmic vesicle; lysosomal membrane; and sarcolemma. Part of protein-containing complex. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease (multiple); Pick's disease; dilated cardiomyopathy 1U; frontotemporal dementia; and hidradenitis suppurativa. Orthologous to human PSEN1 (presenilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Psen1 Products(1)

mRNA	Protein	Name
NM_019163.4	NP_062036.2	presenilin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	15456764	RGD
enables peptidase activity	IDA IDA: Inferred from direct assay	15456764	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12297508	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cerebellum development	IEP IEP: Inferred from expression pattern	16298244	RGD
involved in membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	17433308	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	11895366	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11895366	RGD
involved in neural retina development	IEP IEP: Inferred from expression pattern	12401445	RGD
involved in protein processing	IDA IDA: Inferred from direct assay	15456764	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	11570818	RGD
located in early endosome	IDA IDA: Inferred from direct assay	20126630	RGD
located in lysosomal membrane	IDA IDA: Inferred from direct assay	12736250	RGD
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	12099705	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	16595164	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	20126630	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15456764	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	16595164	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	20126630	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	20126630	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

presenilin-1

PS-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14174	MRK-560	Inhibitor	99.51%	Unkown
HY-125125	Danshenxinkun D	Inhibitor	/	Unkown
HY-156011	PSEN1-IN-1	Inhibitor	/	Unkown
HY-156012	PSEN1-IN-2	Inhibitor	/	Unkown
HY-P1378	β-Amyloid (1-43)(human)		/	Unkown
HY-P1378A	β-Amyloid (1-43)(human) TFA		/	Unkown
HY-RS11276	PSEN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18076	Psen1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24551	Psen1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Psen1	NCBI	NCBI:5663

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