Areg - amphiregulin Gene

Rattus norvegicus

Gene ID: 29183 | Gene type: protein coding

About Areg

Summary

Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in several processes, including negative regulation of osteoblast differentiation; neurogenesis; and response to cAMP. Located in extracellular space. Used to study high grade glioma. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human AREG (Amphiregulin). [provided by Alliance of Genome Resources, Apr 2022]

Areg Products(1)

mRNA	Protein	Name
NM_017123.2	NP_058819.1	amphiregulin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables epidermal growth factor receptor binding	IDA IDA: Inferred from direct assay	15509566	RGD
enables growth factor activity	IDA IDA: Inferred from direct assay	2234093	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15509566	RGD
involved in glial cell proliferation	IDA IDA: Inferred from direct assay	2234093	RGD
involved in negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15509566	RGD
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	1530950	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15509566	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8621257	RGD
involved in positive regulation of phosphorylation	IDA IDA: Inferred from direct assay	15509566	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	16088955	RGD
involved in response to glucocorticoid	IMP IMP: Inferred from mutant phenotype	1530950	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	8806670	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16088955	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	16088955	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	2234093	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

amphiregulin

AR	SDGF
schwannoma-derived growth factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00892	AREG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17019	Areg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23462	Areg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Areg	NCBI	NCBI:374
Mus musculus	Areg	NCBI	NCBI:11839

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