HSPA9 - Hspa9 heat shock protein family A (Hsp70) member 9 Gene

Rattus norvegicus

Also known as Crp40; PBP74; GRP-75; Hspa9a

Gene ID: 291671 | Gene type: protein coding

About HSPA9

Summary

Enables chaperone binding activity; Fibroblast Growth Factor binding activity; and heat shock protein binding activity. Involved in several processes, including cellular response to interleukin-1; response to folic acid; and response to thyroxine. Located in mitochondrion. Biomarker of Parkinsonism and brain ischemia. Human ortholog(s) of this gene implicated in Parkinson's disease and autosomal dominant sideroblastic anemia 4. Orthologous to human HSPA9 (heat shock protein family A (HSP70) member 9). [provided by Alliance of Genome Resources, Apr 2022]

HSPA9 Products(1)

mRNA	Protein	Name
NM_001100658.2	NP_001094128.2	stress-70 protein, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	10510314	RGD
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	15030183	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9538267	RGD
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	9694873	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium import into the mitochondrion	IMP IMP: Inferred from mutant phenotype	17178908	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	15621568	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	7811387	RGD
involved in response to folic acid	IEP IEP: Inferred from expression pattern	16251605	RGD
involved in response to thyroxine	IEP IEP: Inferred from expression pattern	21563808	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	7901206	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17178908	RGD
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	17178908	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

stress-70 protein, mitochondrial

75 kDa glucose-regulated protein	GRP 75
catecholamine regulated protein 40	heat shock 70 kDa protein 9
heat shock 70kDa protein 9A	heat shock protein 9
heat shock protein family A member 9	heat shock protein, A
mortalin	mtHSP70
peptide-binding p

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152153	GRP78-IN-3	Inhibitor	99.98%	Unkown
HY-RS06437	HSPA9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18519	Hspa9 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25001	Hspa9 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	HSPA9	NCBI	NCBI:3313

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